Friday, 1 November 2013

Grapefruit Seed Extract - Alternative Medicine for Dogs and Cats

In this article...
1. Grapefruit Seed Extract
2. Health Benefits
3. Cautions
4. Side Effects
5. Drug Interactions
6. Administration and Dosage 

1.0 Grapefruit Seed Extract (GFSE)

Grapefruit is a citrus fruit. Extract from the seeds of the grapefruit are valued for their medicinal qualities. The benefits of Grapefruit Seed Extract (GFSE) were first noted in 1972 by physicist Dr. Jacob Harich who observed its broad spectrum use as an antibacterial and antiviral remedy. You can read more about Dr. Jacob Harich and the history of GFSE here. University of Georgia researchers determined that GFSE is an effective antiviral, anti-fungal, anti-parasitic agent.

Grapefruit seed extract is not a 100% natural product. The manufacturing process to make GFSE involves intense processing. GFSE is made with pulverized grape fruit seeds, ammonium chloride, glycerin, hydrochloric acid, natural enzymes, vitamin C.  

GFSE is an alternative medicine. It should be used with desecration, meaning used only when necessary. It should not be used on a daily long-term basis. It can be used as an alternative to MRSA-causing conventional antibiotics.

Grapefruit seeds contain active ingredients that are:

  • Anti-bacterial;
  • Anti-fungal;
  • Anti-inflammatory;
  • Anti-microbial; 
  • Anti-parasitic and more. 
2.0 Health Benefits - a partial list..

Ingested Uses

  • Atherosclerosis (hardening of the arteries);
  • Bacteria;
    • GSE has been proven to fight 800 bacterial and viral strains;
  • Cancer;
  • Digestive issues due to eczema;
  • Fungi;
    • Fungal infections;
    • GFSE has been proven to fight 100 strains of fungi;
  • Immune system support;
    • GFSE contains:
      • Hesperidin (a bioflavonoid), well known for its potent immune system benefits; 
      • Vitamin C - citric  acid;
      • Plant sterols, and;
      • Multiple additional antioxidants that aid the immune system’s ability to battle infections.
  • Parasites;
    •  A multitude of single and multi-celled parasites.
  • Skin diseases;
  • Speed healing of wounds;
  • Viruses
    • for example;
      • Upper respiratory tract infections;
      • Colds;
      • Flu (influenza).

Topical Uses

  • Treatment and remedy of:
    • Bacterial infections - ie. dental treatment of the teeth and gums, such as gingivitis.
    • External injuries (wounds);
    • Fungal infections;
    • Skin diseases;
      • Psoriasis

3.0 Cautions...
  • Never give undiluted!
  • Use only when needed for a course of treatment and then stop use - don't use daily long-term.

4.0 Side Effects...
  • Like any substance, certain individuals may be hypersensitive to GFSE. In which case cease use.

5.0 Drug Interactions...
  • Are many - the following is a partial list...
  • Artemether;
  • Buspirone;
  • Carbamazepine;
  • Carvedilol;
  • Cispride;
  • Clomipramine;
  • Cyclosporine;
  • Dextromethorphan;
  • Erythromycin;
  • Estrogen medications;
  • Etoposide;
  • Fexofenadine;
  • Itraconazole;
  • Medications changed and/or broken down by the liver;
  • Medications for high blood pressure (calcium channel blockers);
  • Saquinavir;
  • Statins (medications for lowering cholesterol);
  • Sildenafil;
  • Methylprednisolone;
  • Praziquantel;
  • Quinidine;
  • Scoplamine;
  • Sedative medications (Benzodiazepines);
  • Terfenadine;
  • Theophylline;
  • Warfarin

6.0 Administration and Dosage…

GFSE Can be Administered Two Ways
  • Pulverized seeds can be used as an ingested treatment sprinkled on top of food;
  • Pure grapefruit seed extract drops can be mixed into the food.
  • Liquid GFSE:
    • Minimum dosage:
      •  0.5 drops per every kg (per every 2.2 lbs) of body weight.
    • Maximum dosage:
      • 10 to 15 drops per every 10 lbs of body weight 3 times a day;
  • Pulverized GFSE:
    • 8 mg per every kg (per every 2.2 lbs) of body weight.

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Article and graphics by Karen Rosenfeld. 


  1. I am so thankful for this information. I am still trying to treat my cat. She does eat the food with the grafefruit seed extract after awhile, but she's still sneezing and she's still peeing frequently. I'm going to keep giving her the grapefruit seed extract because otherwise she seems really healthy.

  2. Fantastic information! TY for all the info you share on your website. My friend is using GSE as part of a regime to rid her precious dog of a chronic, systemic yeast infection. She's also changed to feeding the correct, raw meat and bones diet.


Important Note

1.0 Use of Foods, Herbs, Alternative Medicines:

Safe use of items and protocols in the article above, is your sole responsibility.

Foods, herbs and alternative medicines have health issue, condition and conventional drug interactions. Safe use of all substances and protocol are your responsibility.

Before you use any substance or protocol do your research. Check for cautions, contradictions, interactions and side effects. Do not use substances or protocols not suitable to your animal's individual circumstances.

If your animal has an underlying condition substances and protocols may conflict.

2.0 Definition of Holistic…

Food, herbs, alternative medicines are NOT ‘holistic’ they are a substance and MAY, or may NOT be ‘NATURAL’.

If you use a ‘natural’ substance (ie. an herb) you are using a natural substance, not a holistic substance.

Holistic is not defined by use of one or several substances. Holistic is an approach.

Definition of “holistic” from the Cambridge Advanced Learner's Dictionary & Thesaurus © Cambridge University Press


"relating to the whole of something or to the total system instead of just to its parts"

"Holistic medicine attempts to treat the whole person, including mind and body, not just the injury or disease."

Holistic is a way of approaching life, and within that health, and well-being.

3.0 Expectation a natural substance remedies a health or behavioral situation.

A natural substance used to treat symptoms. But, if factors causing the underlying issue remain you do not have a remedy.

Remedy requires a comprehensive approach. It is necessary to identify root cause. Remove items that trigger, cause or otherwise contribute to issues. Holistic approach includes design, implementation to treat, remedy and maintain long-term health.

4.0 Leave a Comment

I review all comments and publish those deemed appropriate for this site.

I answer questions deemed appropriate when I have time to do so.

Wishing your dog and cat the best of health!

Karen Rosenfeld
Ottawa Valley Dog Whisperer
Holistic Behaviorist - Dogs
Holistic Diet Nutrition Wellness Adviser – Dogs and Cats