Grapefruit Seed Extract - Alternative Medicine for Dogs and Cats

grapefruit seed extract, an alternative medicine for dogs and cats

*4 min read 
In this article:
  1. About Grapefruit Seed Extract 
  2. Grapefruit Seed Extract Medicinal Uses
    1. Ingested uses
    2. Topical Uses
  3. Cautions
  4. Side Effects
  5. Drug Interactions 
  6. Administration and Dosage 
    1. Safe methods for administering grapefruit seed extract 
    2. Grapefruit seed extract dosage by bodyweight

1.0 About Grapefruit Seed Extract (GFSE)

Grapefruit is a citrus fruit. Extract from the seeds of the grapefruit are valued for their medicinal qualities. The benefits of Grapefruit Seed Extract (GFSE) were first noted in 1972 by physicist Dr. Jacob Harich who observed its broad spectrum use as an antibacterial and antiviral remedy. University of Georgia researchers determined that GFSE is an effective antiviral, anti-fungal, anti-parasitic agent.

Grapefruit seed extract is not an 100% natural product. The manufacturing process to make GFSE involves intense processing. GFSE is made with: 
  1. Pulverized grape fruit seeds
  2. Ammonium chloride
  3. Glycerin
  4. Hydrochloric acid
  5. Natural enzymes
  6. Vitamin C 
GFSE is an alternative medicine that should be used only when necessary. It should not be used on a daily long-term basis.
Grapefruit seeds contain active components that fight:
  • Bacteria
  • Fungus
  • Inflammation
  • Intestinal parasites (i.e. intestinal worms)
  • Pathogenic microbes

2.0 Grapefruit Seed Extract Medicinal Uses

Ingested Uses for Grapefruit Seed Extract, An Alternative Medicinal Aid For (partial list):
Bacterial infections
Fungal infections
  • GFSE has been proven to fight 100 strains of fungi.
Immune system support, GFSE contains:
  • Citric Acid.
  • Hesperidin (a bioflavonoid), well known for its potent immune system benefits.
  • Plant sterols.
  • Multiple additional antioxidants that aid the immune system’s ability to battle infections.
Intestinal parasites 
Respiratory infections
  • Upper respiratory tract infections
  • Colds
  • Kennal cough, more in this article.
GSE has been proven to fight 800 bacterial and viral strains. GFSE can be used as a temporary aid to help treat:

Topical Uses for Grapefruit Seed Extract (a partial list)

Alternative treatment aid for:

3.0 Cautions

Never use GFSE in undiluted form, for safe use instructions refer to 'administration and dosage' further below.
Use grapefruit seed extract only when needed for a course of treatment, i.e. for 10 days up to 14 days). Then stop use.
Don't use grapefruit seed extract as a daily long-term 'supplement' of treatment. 
If using grapefruit seed extract for more than several days, take extra care to support your animal's gut health, as GFSE kills good and bad bacteria.

4.0 Side Effects

Like any substance, some cats and dogs can be hypersensitive (intolerant or allergic), to GFSE. 
If your dog of cats is hypersensitive to grapefruit or one of the other ingredients in grapefruit seed extract, do NOT use.

5.0 Drug Interactions

A partial list:
  • Artemether
  • Buspirone
  • Carbamazepine
  • Carvedilol
  • Cispride
  • Clomipramine
  • Cyclosporine
  • Dextromethorphan
  • Erythromycin
  • Estrogen medications
  • Etoposide
  • Fexofenadine
  • Itraconazole
  • Medications changed and/or broken down by the liver
  • Medications for high blood pressure (calcium channel blockers)
  • Saquinavir
  • Statins (medications for lowering cholesterol)
  • Sildenafil
  • Methylprednisolone
  • Praziquantel
  • Quinidine
  • Scoplamine
  • Sedative medications (Benzodiazepines)
  • Terfenadine
  • Theophylline
  • Warfarin

6.0 Administration and Dosage

Safe Methods for Administrating Grapefruit Seed Extract
Option One - GFSE Liquid
Pure grapefruit seed extract can be mixed well into food or bone broth
Never dose undiluted in any method including directly into your dog or cat's mouth. Always mix well into food or broth.  
Failure to administer as advised above can result in severe burns to your animal's skin, oral cavity, upper digestive tract.
Option Two - GFSE Powder
Pure GFSE powder can be mixed directly into your dog or cat's food, or put into capsules.
Grapefruit Seed Extract Dosage by Body Weight
Liquid GFSE Dose

Minimum dosage:
  •  0.5 drops per every 1 kg/2.2 lbs of body weight, administered 1x to 3x per day.
Maximum dosage:
  • 10 to 15 drops per every4.5 kg/10 lbs of body weigh, administered 1x to 3x times per day.
Powder GFSE Dose
  • 8 mg per every 1 kg/2.2 lbs of body weight.
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Article by Karen Rosenfeld

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